Test-bed 1: Mesenchymal Stromal Cells

Test-bed 1 projects encompass activities across all aspects of a closed-loop manufacturing system for mesenchymal stromal cells (MSCs). MSCs are currently being explored for their anti-inflammatory and pro-regenerative potential to treat a wide range of chronic diseases.  However, issues remain in scaling these therapies, as well as identifying critical quality attributes for clinical potency.  Our current projects address these major roadblocks:

Projects

• Identification of MSC critical quality attributes through non-destructive, in-process characterization of cellular outputs (Thrust involved 1,3)
• Development of Image-Based Approaches for Predicting and Assessing the Effects of Manufacturing Environments on MSCs (Thrust involved 1,3)
• Microcarriers for Scale-up and Monitoring of MSCs (Thrust involved 1,3)
• Leveraging mitochondrial bioenergetics for long-term quality control and near-term optimization of live MSC potency (Thrust involved 2)